Scroll News
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
  • Tech
    • App News
    • Gadgets
  • Auto
  • Others
    • Sports
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
Scroll News
No Result
View All Result
Home Science

Study gains new insights into Alzheimer’s

Scroll News by Scroll News
November 26, 2021
in Science
0
Share on FacebookShare on Twitter

New Delhi, Nov 26: Efforts to unravel the mystery around the highly debilitating disease of Alzheimer’s have got a shot in the arm with a recent study getting newer insight into the biomolecular mechanism for the formation of protein clusters/aggregates that are often seen in the disease.

Proteins are essential for virtually every process within the cell. But they can also pose problems if they undergo what is called the process of aggregation and/or misfolding. There are more than 50 diseases that are associated with protein aggregation/misfolding. Generally, when proteins get aggregated or misfolded, they deposit around the cells and kill them, leading to the onset of diseases.

You May Also Like This

Young Scientist R. Vishnu Prassad from Chennai conferred Times Award

Young Scientist R. Vishnu Prassad from Chennai conferred Times Award

July 4, 2022

CSIR-IICT establishes new pilot plant facility

December 29, 2021

Science Minister recalls role of scientists in freedom movement

December 2, 2021

In Alzheimer’s disease, studies had so far shown that it was linked with the deposition of misfolded peptides called amyloid β42 (Aβ42) in the spaces between nerve cells. Aβ42 is a peptide derived from a protein molecule called Amyloid Precursor Protein (APP).

The new study has taken this understanding to the next level. Signal peptides are short peptide units present at what is called the N-terminus of the proteins. They act as a postal address for the proteins inside the cell. Usually, as the protein reaches its destination, the signal peptides are cut off from the proteins and often degraded by the cellular machinery. The new study has shown that these peptides can also combine with other peptides to form mis-folded aggregates like Aβ42 and co-assemble with it.

Leader of the study and Associate Professor, School of Basic Sciences, Indian Institute of Technology (IIT) – Mandi, Dr.RajanishGiri, noted that their study was the first report on an aggregation of signal peptides in isolation and said It will help in the future research that could provide the relation of other signal peptides to disease pathogenesis.

“In Amyloid precursor protein, so far only Aβ region was known to form toxic aggregates. Here, we discovered that the Signal peptide of Amyloid precursor protein not only forms cell-killing aggregates but also enhances the aggregation of Aβ42 peptide, under in-vitro conditions.”

The study was conducted by an inter-institutional team. Besides Dr.RajanishGiri, it consisted of his research scholars, Dr.KundlikGadhave and Ms. Taniya Bhardwaj, and Prof. Michele Vendruscolo from the University of Cambridge, UK, and Prof. Vladimir Uversky from the University of South Florida, USA. They have published a report on their findings in the journal ‘Cell Reports Physical Science’. (India Science Wire)

Tags: Alzheimer’sbiomolecular mechanismdebilitatingdiseaseIITIndian Institute of Technologyinsightnerve cellpathogenesispeptideprotein clusterUniversity of CambridgeUniversity of South Florida
ShareTweetShareShareSendSend
Previous Post

Harman Ralh: Digital Marketer Turned Musician

Next Post

Shubham Shourya’s directorial debut silent short film Kaarigar receives overwhelming response

Related Posts

Young Scientist R. Vishnu Prassad from Chennai conferred Times Award
Science

Young Scientist R. Vishnu Prassad from Chennai conferred Times Award

July 4, 2022
Science

CSIR-IICT establishes new pilot plant facility

December 29, 2021
Science

Science Minister recalls role of scientists in freedom movement

December 2, 2021
Science

Blood-based biomarkers for brain tumours identified

November 22, 2021
Auto

A new protocol to address security and privacy issues in electric vehicles

October 27, 2021
Science

A new water repellent material for improved wearable motion sensors

October 4, 2021
Next Post

Shubham Shourya’s directorial debut silent short film Kaarigar receives overwhelming response

Shri Jayesh Ranjan, presents the prestigious ‘Pride of Telangana Awards’ to the unsung heroes!

South India’s biggest Goushala, Satyam Shivam Sundaram GauNivas organised Annakut Celebrations on Sunday

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recommended

SATHYAPRIYA MANIAN: Empowering Individuals and Changing Lives with a Holistic Approach

SATHYAPRIYA MANIAN: Empowering Individuals and Changing Lives with a Holistic Approach

2 years ago

WHY branded drugs cost more than their generic counterparts?

4 years ago
Institute of Bakery & Culinary Arts (IBCA) announces admissions for their various programs

Institute of Bakery & Culinary Arts (IBCA) announces admissions for their various programs

3 years ago

Treatment for Rabies could soon be within reach

4 years ago

Categories

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Gadgets
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World

Topics

Ace Entrepreneur actor Artificial intelligence Bangalore Bengaluru Blockchain technology BRICS CCI Content Creator COVID-19 Cryptocurrency CSIR DBT Delhi Digital Marketing DST Dubai Education entrepreneur entrepreneurship Fairplay Gujarat Gurugram Hyderabad IIT Delhi India Indian Institute of Technology Influencer Influencerquipo innovation Kingston Technology K Raheja Corp Homes memory products and technology solutions Mumbai Music Industry pandemic photography producer Pune real estate research Shan Se Entertainment Shantanu Bhamare social media Surat technology
No Result
View All Result

Highlights

ClinicSpots Digital Services: Empowering Healthcare Brands with Proven Digital Growth

Mark Rober’s Indian Expedition: A Confluence of Creativity, Collaboration, and Innovation

Dr. Vipulroy Rathod Leads Early Detection of Digestive Cancers Through Advanced Endoscopic Evaluation and Treatment in Mumbai, India

Aveya IVF & Fertility Center: Pioneering Accessible Parenthood with Fertility Solutions

Krishiyug Inovatives Pvt. Ltd.: Where Ancient Farming Wisdom Meets Rural Empowerment

Rice Over Bread: How Lenexis Foodworks Captured India’s Chinese Food Market

Trending

Kingston Powers Tomorrow: Enabling the Future of AI with High-Performance Solutions at COMPUTEX 2025
Tech

Kingston Powers Tomorrow: Enabling the Future of AI with High-Performance Solutions at COMPUTEX 2025

by Scroll News
May 22, 2025
0

Taipei, May 22, 2025: Kingston Technology, a world leader in memory products and technology solutions, returns to...

Invisalign Treatment Delivers Predictable Results for Adult Patients, Achieving Complete Space Closure in as Little as 8 Months

Invisalign Treatment Delivers Predictable Results for Adult Patients, Achieving Complete Space Closure in as Little as 8 Months

May 20, 2025
Quick Scaleup Technologies: How a Patna-Based Startup is Powering Global Digital Growth

Quick Scaleup Technologies: How a Patna-Based Startup is Powering Global Digital Growth

May 20, 2025
ClinicSpots Digital Services: Empowering Healthcare Brands with Proven Digital Growth

ClinicSpots Digital Services: Empowering Healthcare Brands with Proven Digital Growth

May 20, 2025
Mark Rober's Indian Expedition, Mark Rober, engineer, inventor, YouTuber, former NASA scientist

Mark Rober’s Indian Expedition: A Confluence of Creativity, Collaboration, and Innovation

May 17, 2025
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

© 2022 Scroll News

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 Scroll News